Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection Research Published on 2022-08-062022-10-05 Journal: Nature Communications [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] analysis Analysis bilateral pneumonia Blood COVID-19 COVID-19 progression COVID-19 severity Cytokines death described DNA genotyping DNA methylation Dyspnea epigenomic evaluate functional genetic loci genetics IL-6 expression immune Inflammatory Interaction involved many cases Mild pathway progression regulates Regulation reveal SARS-COV-2 infection Severe case severe cases syndrome the cytokine storm transcription factor triggering with COVID-19 [DOI] 10.1038/s41467-022-32357-2 [Article Type] Research
Integrating 3D genomic and epigenomic data to enhance target gene discovery and drug repurposing in transcriptome-wide association studies Research Published on 2022-06-072022-10-05 Journal: Nature Communications [Category] 신약개발, 유전자 메커니즘, 임상, 치료제, [키워드] approach association competing Computational drug conformation ENhance epigenomic epigenomics eQTL expression expressions extension gene expression level genomic help increase independent Informed loci median Model outperform predict prediction Quantitative Region target gene traits transcriptome-wide variants [DOI] 10.1038/s41467-022-30956-7 [Article Type] Research
Variant to function mapping at single-cell resolution through network propagation Research Published on 2022-06-062022-10-05 Journal: Nature biotechnology [Category] 유전자 메커니즘, [키워드] Algorithm Analysis approach association Blood causal variant cell types cellular Combination COVID-19 developmental epigenomic Genetic variation help Hematopoiesis human genetic variation identify Inference leukemia lymphocyte mechanism monocyte network propagation overcome provide risk single-cell single-cell genomic Stage subset trajectory [DOI] 10.1038/s41587-022-01341-y [Article Type] Research
Genetic Landscape of the ACE2 Coronavirus ReceptorACE2 코로나바이러스 수용체의 유전적 지형Meta-Analysis Published on 2022-05-032022-09-11 Journal: Circulation [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] ACE2 ACE2 protein Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biological systems blood immune cells cardiometabolic cardiovascular disease cardiovascular diseases cardiovascular diseases. Cell cell type circulating Clinical studies clinical study Combined complex complex disease conducted coronavirus correlated correlation COVID-19 COVID-19 severity cross-sectional Diseases DNA methylation elevated epidemiological epigenomic expressed functional gastrointestinal tracts Genetic genetic architecture Genome genome-wide association Genome-wide association study heart heritability Hospitalization Human human cell human cells immune cells in silico individual Infection landscape likelihood loci mapped medications mendelian randomization Meta-analysis Odds ratio outcome Phenotypes plasma Protein Quantitative randomization receptor Regulatory related diseases resource respiratory SARS-CoV-2 severe COVID-19 soluble ACE2 suggested tissue transcriptomic Treatment variant Vascular vascular disease vascular diseases [DOI] 10.1161/CIRCULATIONAHA.121.057888 PMC 바로가기 [Article Type] Meta-Analysis
Severe COVID-19-associated variants linked to chemokine receptor gene control in monocytes and macrophages단핵구 및 대식세포의 케모카인 수용체 유전자 조절과 관련된 심각한 COVID-19 관련 변이체Article Published on 2022-04-142022-09-11 Journal: Genome Biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] 3D genome organization 3p21.31 association CCR1 CCR2 CCR5 Chemokine receptor chromatin Control COVID-19 CTCF elevated epigenomic Gene regulation Genes Genetic genetic association Genome Genome-wide association studies GWAS hallmark Hospitalization increased expression infiltration inflammatory monocyte inflammatory monocytes locus Macrophage macrophages mechanism monocyte Monocytes organ rationale Regulatory regulatory element risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. severe COVID-19 SNP variant [DOI] 10.1186/s13059-022-02669-z PMC 바로가기 [Article Type] Article
Epigenomic and transcriptomic analyses reveal differences between low-grade inflammation and severe exhaustion in LPS-challenged murine monocytesArticle Published on 2022-01-282022-10-04 Journal: Communications Biology [Category] 바이오마커, [키워드] analysis analyzed bacterial endotoxin Characteristics Chronic diseases chronic inflammation condition contribute COVID-19 driving Epigenetic epigenomic epigenomics evaluate expression Gene Expression Genes High dose High-dose immune induce Inflammation interferon response low dose low-dose low-grade inflammation LPS marrow-derived macrophage memory Modification monocyte murine occur Pathogenesis pathogenic pathway Pathways PBS proliferative Regulation responses Sepsis Signaling target the cell therapeutic TLR4 transcriptomic underlie upregulate while [DOI] 10.1038/s42003-022-03035-2 PMC 바로가기 [Article Type] Article
Viral and Host Genetic and Epigenetic Biomarkers Related to SARS-CoV-2 Cell Entry, Infection Rate, and Disease SeverityReview Published on 2022-01-232022-10-28 Journal: Biology [Category] COVID-19, [키워드] ACE2 receptor addition affecting Analysis binding Biomarker Biomarkers caused Cell Characteristics coding common contribute coronavirus Course COVID-19 COVID-19 susceptibility database Defense disease DNA methylation Epigenetic epigenetics epigenomic Evolution expression Factor feature gene silencing Genes Genetic genetic variability genetics genomic global pandemic help high mortality rate Host host cell host gene human gene immune system Infection inflammatory pathway interfere investigated mechanism miRNA molecular morbidity Mortality Mutagenesis Mutation new strain non-coding region Ontology outbreak outcome outcomes pathway performed Polymorphisms predict Predictive Prognosis prognostic biomarker Protein Rate Regulation Replication responsible RNA expression SARS-CoV-2 SARS-CoV-2 entry severity simple spread of COVID-19 Still susceptibility the disease the spike protein transcription factor Transmission Treatment Treatment response tumour suppressor viral entry viral genome Viral RNA virus virus–host interactions [DOI] 10.3390/biology11020178 PMC 바로가기 [Article Type] Review
Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19말초 면역 세포의 단일 세포 후성유전체 환경은 COVID-19에서 회복 중인 개인의 훈련된 면역 확립을 보여줍니다Article Published on 2021-06-012022-09-11 Journal: Nature cell biology [Category] SARS, 유전자 메커니즘, 임상, 치료기술, 치료법, [키워드] accelerated activated acute respiratory syndrome acute respiratory syndrome coronavirus adaptive analysis Analysis antibody asymptomatic infection B cell B-cell cause CD14 CD16 CD8 chromatin collected coronavirus coronavirus 2 COVID-19 death developmental differentiation epigenomic exhibited expansion healthy donors highlighting immature Immune cell immune cells immune response immune responses Immunity Immunological memory individual individuals Infection IRF1 Lineage Memory cells monocyte Monocytes mononuclear cell performed Peripheral blood Peripheral blood mononuclear cells Plasma cells profile promote reported reveal SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe complication severe complications single-cell T cell T cells [DOI] 10.1038/s41556-021-00690-1 PMC 바로가기 [Article Type] Article
Genomic, epigenomic, and immune subtype analysis of CTSL/B and SARS-CoV-2 receptor ACE2 in pan-cancer범암에서 CTSL/B 및 SARS-CoV-2 수용체 ACE2의 게놈, 후성유전체 및 면역 아형 분석Research Paper Published on 2020-11-302022-09-10 Journal: Aging (Albany NY) [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] ACE2 addition Analysis analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 association bioinformatics Cancer cathepsin cathepsin B cathepsin L Cell Cervical copy number COVID-19 CTSB CTSL CTSL/B Cystadenocarcinoma demonstrated DNA methylation endocervical enzyme epigenomic Gene Expression genetic alterations healthcare IFN-gamma immune International Methylation negative correlation ovarian overexpressed positive correlation potential risk present Prognosis protease receptor Result risk risk factor RNA expression SARS-coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor serous Cystadenocarcinoma Society Squamous cell Squamous cell carcinoma stomach subtype upregulation urothelial carcinoma [DOI] 10.18632/aging.104147 PMC 바로가기 [Article Type] Research Paper